The natural occurrence of sedoheptulose monophosphate in liver.

Our present inter& in the metabolism of sedoheptulose originated unexpectedly from the discovery of its monophosphate as a product of incubation of rat liver supernatant and adenosine (I). In the course of this work, a process was devised for isolating the sedoheptulose monophosphate product and for preparing from it, scdohcptulosan, in pure crystalline form. The principles which were the basis of that research have now been utilized in a search for sedoheptulose phosphate in calf liver. This mctabolite has now been isolated and has been characterized not only as the phosphate-free crystalline sedoheptulosan but also as crystalline scdohcptulosan tetrabenzoate. In this paper, an account of these results is presented.